I don't think small vessel disease of the brain is well understood and it is difficult for any doctor to prepare one for what to expect. Symptoms occur due to changes to different parts of the brain so vary from one person to the next. Dr Michael Zeineh of Stanford University has been in the news recently about a relationship between Chronic Fatigue Syndrome and White Matter brain changes. Keep in mind that brain changes are more extensive in some patients more than others. Hopefully those with less will live to learn bio markers are confirmed that will lead to treatment. Presently my research has not turned up much other than controlling cholesterol, Blood pressure, thinning blood which is basically stroke prevention. Best to all.