I had a unilateral mastectomy on 7/19 and a drain was put it. However, the drain didn't work because there was a blood clot under the skin. I kept calling about it and kept getting reassured. When it was after hours, a bunch of fluid came out onto my clothes! When I saw my surgeon for 1 week post-op, she could see the problem and removed the drain. She then used a syringe to aspirate the seroma, had me continue wearing compression around my chest. I returned and was aspirated 3 more times (?) and it kept coming back. Another drain was put in at this point and it functioned for the next two weeks and finally the amount of fluid started to decrease. She took out the second drain and now we are waiting 3 weeks to see if the smaller amount of fluid will get absorbed and allow the skin to grow together so there will be no more pocket in which the fluid can gather. I am hopeful that we can be done with this in the next couple of weeks. More of an annoyance than anything. Mine hasn't been painful but it's required multiple trips to the office. Wishing you speedy resolution!