I had nausea and headaches that lasted 1-3 hours after injecting for the first 6 months I was on Tymlos. Really hated it! But I stuck with it because my osteoporosis is severe and there was no question that I needed strong medical intervention. It has helped increase my bone density, and side effects are infrequent and much shorter-lived now.

Many people who had bad side effects when starting Tymlos either injected every other day, or else adjusted the dose of their daily injection, slowly increasing to the full dose. These strategies didn't work for me. But if you are desperate for help, try to put up with the side effects and see if they wane as the weeks go by. As for weight loss: I too, am very slim, bordering on underweight, but didn't lose further because of the Tymlos. And when my weight drops too low, I resort to milkshakes! 🙂 Also, you can only be on Tymlos for 18 months, so you can always gain weight back if you do lose.

BTW, it seemed to help me to inject after dinner, on a full stomach.