Note that all of the heavy duty drugs have potential serious risks, including Humira.

I developed neuropathy in my feet and lower legs 2 or 3 weeks after I started Humira. The neurologist told me that this is a common side effect of TNF blockers (including Humira). Then I had a stroke 3 or 4 months later. The doctors were split on whether it was caused by Humira or severe ulcerative colitis inflammation.

Humira also did not do me any good. So I next tried Entyvio, then Stelara and finally Rinvoq. Rinvoq was the only one that worked for my UC.

Fortunately I personally did not experience any significant adverse effects with these drugs other than Humira. But in each case my GI doctor advised that the potential risks were real, though after evaluating my situation we agreed the potential benefits justified taking the potential risks. If my UC inflammation had not been so severe, we might have reached different conclusions.

Everyone is different, so it is very difficult to figure out what to do. There are also a lot of continuing developments - both in terms of new drugs and what is known about existing drugs. Hopefully you can find someone with IBD experience who can recommend another drug or otherwise how to best manage your UC.