I have osteoarthritis. I had it before Prolia injections. I started Prolia 18 months ago. I also take collagen. I have had less osteoarthritis pain as of 1 year ago. I don't know whether to attribute that to Prolia or the collagen. However, I made a huge increase in my spine density in one year. I went from a -4.2 to a - 3.6. Perhaps that has helped my bone pain.