Hey juju01, in answer to your question about medications that can be administered into a joint to ease the pain of OA and increase mobility, you'll want to talk to your doctor or surgeon about Hyaluronic Acid. It's extracted from the combs of roosters and is injected directly into the afflicted joint. It reduces the pain by reducing the inflammation, and binds to the joint surface. This smooths the surface and allows better movement. But remember, this is not a permanent solution. Some people get very minimal benefit, but most get good results that last about a year. Some choose to go with annual injections and completely forego surgery. My neighbour and I have both had Synvisc in our knees, he annually for several years, me twice.