Hi @patriciaschulz1950, Welcome to Connect. I'm thinking I might have the same feelings and questions that you do and it's always good to ask questions that your neurologist or doctor can hopefully answer so that it's easy to understand. Here are a few references that might be helpful to understand how it works.

--- Nutritional Neuropathies: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199287/
--- The Role of Vitamin B6 in Peripheral Neuropathy: A Systematic Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343656/.

I shared my neuropathy journey in another discussion here - https://connect.mayoclinic.org/comment/310341/. I take 4000 mcg Methylcobalamin B12 daily as part of my neuropathy supplements. Here's a reference link on the B2 - https://austinpublishinggroup.com/pharmacology-therapeutics/fulltext/ajpt-v3-id1076.php. I would be more concerned with taking additional B6 if my levels were already high since you can get B6 toxicity which can cause neuropathy. There is another discussion on the topic that you might want to read what others have shared here:
--- B-6 vitamin danger!: https://connect.mayoclinic.org/discussion/b-6-vitamin-danger/.

I think I might ask my neurologist why they are not concerned so maybe it would shed more light on your concerns. Do you know how long your B12 and B6 levels have been high or what the possible cause is?