Correlation between peripheral neuropathy and low RBC?

Posted by Ray Kemble @ray666, Jul 1, 2023

I have idiopathic peripheral neuropathy. I've no pain but terrible balance. I also have two swollen feet. Doctors noticed my swollen feet long before I received my PN diagnosis, but they've never figured out why. I also have a low RBC (red blood count), for which I have seen a hematologist; he didn't appear to be terribly alarmed. I'm wondering: Do any of you with PN also have swollen feet? And has anyone (doctor-type) linked it to your PN? Same thing for a low RBC: Have any of you had a low RBC connected in some credible way to your PN? I'd sure love to know.

Ray (@ray666)

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@larry4343

I have both idiopathic PN and large red blood cells (Macrocytic anemia). My rbc count is also low. I’ve had it a long time and my neurologist isn’t interested in it as a possible cause, but some anemias are known to be causal so your mileage may vary.
Fwiw, I think it’s logical that even a mild, long term condition like that could cause a slowly developing case of neuropathy - and that modern medical practice would ignore it; They’re only interested when the causality is incontrovertible. Best of luck with your case.

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Good morning, Larry–– You've touched on precisely what was on my mind: Is there even the remotest possibility of a connection between neuropathy and some other chronic condition––or, in our case, between neuropathy and a low RBC? Please don't misunderstand me: I trust my doctors; I believe they're capable, caring people. However, what disappoints me is sensing not the least curiosity when I ask about a possible connection between one condition and another. It is as if––as you say––when a connection is not incontrovertible (or solidly within a doctor's specialty), there's little reason to pursue the matter. Best of luck to you, too! ––Ray

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@michhino

I am a diabetic since 2017 and diabetic neuropathy started with my feet (tingling, numb, painful nerve strikes, etc..) in 2018 which nerve damages eventually spread into my calves and thighs plus waist. Until this day(2023), I have been dealing with unmanaged/uncontrollably diabetes II and painful neuropathy.

After all the doctors, neurologist, emergency rooms, hospitals, etc.. , plus prescribed medications (gabapentin, Juniva, Metformin, Duloxetine, etc.. I completely regret to spend thousands and thousands of dollars (Out of Pocket and/or Insurance)…

After 5 years with such conditions, you DO NOT want the neuropathy (nerve damage) to quickly grow and affect your entire feet, calves, thighs, and hands as it is an extremely terrible feeling along with very poor state of mind, anxiety, stress, daily activities, etc..

Sadly, REAL answer for these serious mental and health complications and conditions were experienced as "NO CURE" ! The only solution provided is to amputate feet, legs, and hands. I could not live with myself with such situation as I will continue to suffer and convince mind it is part of the remaining part and style of my life.

I adopted a 5 year dog to help encourage walking at least 4 times a week.

My advice is to eat healthy, exercise, and most definitely "Save your Money"…

My prayers are with you ...

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@michhino : Type 2 diabetes, can be cured! That is the good news! It is a disease of choice according to many scientists. The "cure" is simply changing what you eat and adding some exercise. My sister has been overweight for years and in her late 50's developed T2 diabetes. Her doctor told her to start eating primarily vegtables and some fruits. She gave her a book of recipies. After only 2 months she was cured!! Gone! But old habits die hard and after a couple of years she slipped back into her old habits and the diabetes came back. So this has to be a lifetime commitment. But look at all the misery, pain and cost that will be avoided! No neuropathy is a HUGE benefit right there as we all know that once you get it you are stuck with it.

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@crossette

@michhino : Type 2 diabetes, can be cured! That is the good news! It is a disease of choice according to many scientists. The "cure" is simply changing what you eat and adding some exercise. My sister has been overweight for years and in her late 50's developed T2 diabetes. Her doctor told her to start eating primarily vegtables and some fruits. She gave her a book of recipies. After only 2 months she was cured!! Gone! But old habits die hard and after a couple of years she slipped back into her old habits and the diabetes came back. So this has to be a lifetime commitment. But look at all the misery, pain and cost that will be avoided! No neuropathy is a HUGE benefit right there as we all know that once you get it you are stuck with it.

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Crossette; It may appear that you may not experience the life of diabetes and PN. Needless to say, I have been fighting diabetes and neuropathy for over 5 years and although with proper foods, exercise, etc. I am not able to find a complete cure for both. Yes, people will react differently on a temporary basis to certain medication, insulin, but from my personal experiences there is ultimately NO CURE even though with proper meals, exercise, etc.. As of course, you can not simply live on veggies and fruit! And yes, I have the food book for T2 diabetes consumption which I no longer believe in. Currently, I continue to remain insulin dependent with few meds such as metformin to drastically and quickly reduce glucose so PN will not be extremely painful. Yes, PN will not disappear and/or be cured BUT if doctors knew on how to help a severe diabetic in the first place instead of anticipating financial gains, I would certainly not be in the sad and devastating painful stages with PN in the first place!!! Now, I continue to deal with both medical situations which have a negative bearing in my life as I move forward. I have molded myself to ignore the pain and discomfort plus accepted it's simply a part of remaining life personally as, NO CURE !

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@mitfit

Ray - That is very interesting. Perhaps it is the PN that is the cause of the foot swelling. I will try compression stockings at night. It is so helpful to talk about these things with others who experience them.

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I have been wearing the compression socks all day. I get swelling were the compression sock ends all the time

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There’s a potential loose association between low RBCs and PN. PN can be associated with MGUS, a bone marrow disorder that is generally benign involving plasma cell overproduction. It can be associated with anemia. A blood test called serum protein electrophoresis (SPE) is done to screen for that. I would ask your Dr to do that test. If abnormal, you would see a hematologist for follow up. A serum total protein and serum albumin can be done along with it. If albumin is low it can cause swelling and is often overlooked as a cause for swelling. I assume your heart, liver and kidney function has been checked already.

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Ray, I have the same problem with balance but no pain, thank God! I also have weak muscles in both legs & swollen feet to boot. I have to use a walker for the imbalance & have started an exercise program to strengthen my leg muscles. I do have some swelling in both feet most of the time. Do you also have leg weakness? Thanks for any input you may have. Barry

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@barryandbrenda

Ray, I have the same problem with balance but no pain, thank God! I also have weak muscles in both legs & swollen feet to boot. I have to use a walker for the imbalance & have started an exercise program to strengthen my leg muscles. I do have some swelling in both feet most of the time. Do you also have leg weakness? Thanks for any input you may have. Barry

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Ray, I failed to mention I also have low RBC and I do wear compression knee high stockings for my leg & foot swelling! Bad balance is my biggest problem! I forgot to include this info in my original note. Barry

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@ray666

Good morning, Larry–– You've touched on precisely what was on my mind: Is there even the remotest possibility of a connection between neuropathy and some other chronic condition––or, in our case, between neuropathy and a low RBC? Please don't misunderstand me: I trust my doctors; I believe they're capable, caring people. However, what disappoints me is sensing not the least curiosity when I ask about a possible connection between one condition and another. It is as if––as you say––when a connection is not incontrovertible (or solidly within a doctor's specialty), there's little reason to pursue the matter. Best of luck to you, too! ––Ray

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I also have had low red blood count and mean cellular volume over 100 for at least 20 years, along with increasing neurological damage and loss of mobility. Last Winter I did a deep Google dive on my symptoms, blood tests, and health history. Only one diagnosis fit—Pernicious Anemia. A hematologist tested my intrinsic factor antibodies. They’re very high, showing that I cannot absorb B vitamins in food. So I began daily self-injections last November. Improvement is gradual after so many years, but many things are better and I finally have hope. I urge you to see a hematologist asap. The specialists I saw suspected all kinds of genetic issues and advised saving for an electric wheelchair (which I may yet need!) PA is especially common after an autoimmune thyroid disease and can run in families. Knowledge is power….

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@larry4343

I have both idiopathic PN and large red blood cells (Macrocytic anemia). My rbc count is also low. I’ve had it a long time and my neurologist isn’t interested in it as a possible cause, but some anemias are known to be causal so your mileage may vary.
Fwiw, I think it’s logical that even a mild, long term condition like that could cause a slowly developing case of neuropathy - and that modern medical practice would ignore it; They’re only interested when the causality is incontrovertible. Best of luck with your case.

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I have same---diagnosis of "MA" only with Absolute Monocytosis---Have you seen a Hematologist? She ordered a Bone Marrow Test which revealed the diagnosis.

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Hello,

I find it interesting that this topic, a topic I created a little over a year ago, has now resurfaced. Although time has passed, I remain interested in what others say.

And by the oddest of coincidences, I have an appointment to see a hematologist a week from tomorrow, the only sit-down with a hematologist since my original post.

Thanks to all of you for reviving the topic. I look forward to reading your comments.

Ray (@ray666)

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