Thank you! Yes, we have a fair amount of near issues in just three generations. My child also developed a mild case of POTS (just barely meets the criteria) and while the PANDAS is in remission, thankfully, they still have significant fatigue due to the pots. In my child's case, there was clearly an association between strep infections and deteriorations. There were a lot of other conditions that were ruled out, including Wilson's (which is a copper metabolism issue so very different treatment). Ultimately, it is still considered a diagnosis of exclusion, as a biomarker hasn't been confirmed yet (although there is ongoing research and my child had various abnormal labs, including complement activation even after the infection was treated and cleared). There have been a couple of studies using MRI and one that used a particular analysis to detect volume changes in the basal ganglia. It took some time for a proper workup and diagnosis, and that was 6 years ago. Their fatigue now looks sort of like mine, but they do not have a fibromyalgia diagnosis. I try to learn everything I can in the hope that they can reach full health and their potential.