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Kappa Light Chains and PN

Posted by Lynsorensen @lynsorensen, Jul 25, 2017

Anyone else been tested for Kappa and Lambda light chins free serum in connection with peripheral neuropathy?

Interested in more discussions like this? Go to the Neuropathy Support Group.

justandie | @justandie | Aug 25, 2023

Please try to maintain a positive attitude. I know it is hard sometimes, but remember that being grateful and hopeful, rather than giving in to despair, is the best thing you can do for a positive outcome. I'm sure many people, including myself, wish you the best. Good Luck!

REPLY
justandie | @justandie | Aug 25, 2023
In reply to @johnbishop "Hello @lynsorensen, I have not heard of kappa light chains before but did find some information..." + (show)
@johnbishop

Hello @lynsorensen, I have not heard of kappa light chains before but did find some information from Mayo Clinic's News Network:
http://newsnetwork.mayoclinic.org/discussion/mayo-clinic-ids-immune-system-glitch-tied-to-fourfold-higher-likelihood-of-death/
I also did a search on Google Scholar (https://scholar.google.com/) using the search term "kappa light chains cause neuropathy" and it found quite a bit of information:
https://scholar.google.com/scholar?as_ylo=2017&q=kappa+light+chains+cause+neuropathy&hl=en&as_sdt=0,24
Hope this helps, also that others jump in the conversation if they have more information.

John

Jump to this post

Thanks for the links, John, but I'm afraid the info they give is way beyond my level of understanding. I do have a slight elevation in my kappa light chains, which my hematologist thinks is just a slight anomaly, and nothing to worry about. But we are going to watch it. Then, since I saw her last October, I have "come up with" a neuropathy (allodynia) on my back. It started very abruptly, unlike the usual diabetic peripheral neuropathy, though I am diabetic.
Do you think I should bring this to her attention?
Thank you.

REPLY
1 reply
Mentor
John, Volunteer Mentor | @johnbishop | Aug 25, 2023
In reply to @justandie "Thanks for the links, John, but I'm afraid the info they give is way beyond my..." + (show)
@justandie

Thanks for the links, John, but I'm afraid the info they give is way beyond my level of understanding. I do have a slight elevation in my kappa light chains, which my hematologist thinks is just a slight anomaly, and nothing to worry about. But we are going to watch it. Then, since I saw her last October, I have "come up with" a neuropathy (allodynia) on my back. It started very abruptly, unlike the usual diabetic peripheral neuropathy, though I am diabetic.
Do you think I should bring this to her attention?
Thank you.

Jump to this post

You bet! I usually write my questions down for my appointments so I don’t forget.

REPLY
bobweller | @bobweller | May 9 10:55am
In reply to @johnbishop "Hello @lynsorensen, I have not heard of kappa light chains before but did find some information..." + (show)
@johnbishop

Hello @lynsorensen, I have not heard of kappa light chains before but did find some information from Mayo Clinic's News Network:
http://newsnetwork.mayoclinic.org/discussion/mayo-clinic-ids-immune-system-glitch-tied-to-fourfold-higher-likelihood-of-death/
I also did a search on Google Scholar (https://scholar.google.com/) using the search term "kappa light chains cause neuropathy" and it found quite a bit of information:
https://scholar.google.com/scholar?as_ylo=2017&q=kappa+light+chains+cause+neuropathy&hl=en&as_sdt=0,24
Hope this helps, also that others jump in the conversation if they have more information.

John

Jump to this post

Thank you. These articles were very enlightening and helps me perform better continued searches. I have had 2 liver transplant since 2000. My kidney appear to be damaged from Prograf/Tacrolimus now. Stage 3B. I had the blood test as part of my continued neuropathy in my feet and starting up each leg. I am waiting to see what the doctors say next since I just got these results online through My Chart. Cancer scars me!

REPLY
mariannelarsen | @mariannelarsen | May 9 11:16am

I have elevated kappa light chains - I was told not to worry about it ??
I have neuropathy in my feet - started in my toes and is now progressing toward my ankles.

REPLY
mariannelarsen | @mariannelarsen | May 9 11:45am

Thank you John for including me in this discussion. I am going to speak to me neurologist about this this - I may have to go to a Mayo doctor to get some more understanding about it. I am especially concerned about my neuropathy getting worse

REPLY
mariannelarsen | @mariannelarsen | May 9 5:53pm

I have - My fr Kappa light chains was 22.8
kappa/Lamba Ratio was 2.40 Both a abnormal
I had it tested again and it all but one (forgot which one)was in the normal range. I have no idea what it means except Multiple Myeloma which I was told I didn’t have. The neuropathy in my feet is getting worse - from
My toes now to my ankle I’m curious to know if these labs have anything to do with neuropathy and want to know - is it just going to continue to go up my legs.

REPLY
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