After trying numerous antidepressants which did quell overwhelming anxiety and depression but also made me too numb (just sat in front of TV with food) I went to 50mg of Pristiq with Xanax back up. That has worked better than anything. After 12 years and many life/family changes I am determined to be drug free again, for reasons outlined elsewhere. These posts have been very helpful and I am working diligently and slowly towards psilocybin therapy as well with experienced professional. Need to have Pristiq out of system for psilocybin to work as intended.