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Kidney Biopsy Complication

Transplants | Last Active: Aug 21, 2023 | Replies (21)

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@hello1234

Hi @caretakermom 😊
It's so great to hear from you! I am so happy you logged on today too so we can catch up!
Yes, most of the time if these av fistulas form in the kidney as a complication after biopsy, they will spontaneously heal within two years (and not cause symptoms). My fistula is not.
Regarding your husband. Your husband, like me, has suffered with the opposite of rejection.
The immune suppression meds were running too high and allowing recurring CMV infection.
I had CMV, then the immune suppression was lowered in half, then I had BK and it was lowered in half again, even now I have 7 million BK urine so the "lowered" meds are staying as my new dosage.
Infection normally occurs when the immune suppression dosage is too high. Rejection normally happens when the immune suppression is too low.
My personal recommendation (not a doctor) is to avoid the invasive test and have the blood test first. If the blood test result is concerning, then go for the biopsy.

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Replies to "Hi @caretakermom 😊 It's so great to hear from you! I am so happy you logged..."

HI @hello1234

So you think the slight elevation of creatinine is due to the lower immune suppressive dosage, and not the AV fistula complication that is present in your transplanted kidney? What can they do to resolve BK virus that is present in your urine? I asked about BK at 1 year checkup and the transplant neph says BK , like CMV, occurs usually during the 1st year of transplant. He says BK/CMV can happen later but very very seldom so he told us not to worry too much about it. But I'll definitely not ignore it and be vigilant.
May I ask how many kidney biopsy protocols have you had post transplant? My hubby's has had 2 (at 4 month and 1 year checkup) and Mayo Az's annual checkup includes kidney biopsy up to the 2 year checkup, however, some of the patients I know only did 1 or 2 max because of COVID when they limited in-person visitation. At 3 year it will just be blood draw labs which can be done locally. After that they do not require any more checkup, unless you experience complications.
Mayo Az recommends the biopsy for all of their transplant patients up to 2 year, because it will help detect early rejections. The transplant neph says it is more reliable than the Prospera test which detects current rejecton. We will discuss with our local neph to get his recommedation(he will probably recommend it because low risk of injury). It's such a difficult decision whether to do the biopsy because it does cary risks of injury and the Prospera lab will not show EARLY rejections which is the reason transplant neph prefers biopsy! There are definitely pros and cons, like everything else in life I'm afraid! I have always understood that risks are real though small in kidney biopsy, but the impact is greater when you actually know someone who is going thru it. Thank you for your advice and bringing this issue to our attention. Please keep us posted on how your treatment goes!