I had a rising PSA a few years after Proton radiation treatment. PET scan shows some mets so started Lupron plus Xtandi (160 mg per day) treatments 18 months ago. PSA dropped to zero or near zero within a 3 months after starting treatments. It is working well so don't plan to change anything at this point; however, I do suffer the typical side effects of fatigue and hot flashes. Hot flashed are mostly controlled with an additional pill.

I took Xtandi for 26 months. Excellent drug. Had fatigue, hot flashes and edema of extremities. Side effects are expected. Remember that your testosterone levels need to be at castration range (less than 50) to help control the cancer and that is what is likely causing your hot flushes. Fatigue is a common side effect of Xtandi. Expect a major drop in your PSA with this treatment. Wish you the best. Stay strong.

Fatigue is the most difficult. But why start with half dose?

I've been on Xtandi for 7 months, Lupron at regular intervals for 9 months prior and intermitent another 4 years prior to that. The hot flashes dimnished after the first several years of Lupron.
The Xtandi is a great drug, having driven my PSA to near zero. In addition to some fatigue, I've experincd sour stomach, but diet adjustments are helping. While I was never a bear, the Xtandi has virtually elimnated body hair, excepting that on my head and face.

PSA went up to 9.8 Xtandi with no side effects brought it down to 1.7 Its 3.0 now so some concern

78 feeling great Zolodex and Xgeva 3 month shots L1 radiate in 2020 L@ has 1 inch but too close to radiate they say

2017 prostate radiated 40 sets

Casodex 30 days next then Zolodex 3 Mos injection

I was on ADT and Erleada ( I have read some places that it is a chemo) and the side effects were manageable and the drugs worked great on my gleason 9 CR locally advanced PC Good luck to you

Well, I follow many contributors regarding PC and various treatments. Let me share my experience. I'm currently 77 years old diagnosed in 2019 with metatisized prostate cancer. During routine physical my PSA was 135 and by the time I saw my urologist it was 245. Biopsies and MRI confirmed cancer, Put on Lupron PSA rapidly dropped to 0,5. Contnued with ADT Lupron only for a year but it clobbered my energy, muscles, skin, hpt flashes so much I stopped in 2020. Changed health plan and new doctor put me back on Lupron, Same but less side effects. PET scans showed prostate and 2 lymph nodes affected. Continued Lupron into 2023 with Erleada added in April. Soon after developed serious rashes ove arms and back. Doc stopped meds. August 1 I underwent enlarged prostate HoLEP treatment. Big success to improve urinary function. Big suprise is prostate tissue analysis tested NEGATIVE for cancer. WHAT? No evidence of prostate cancer after procedure. Result is my doctor and I agreed to stop all further treatment and undergo surveiance PSA monthly testing. Appears I am cancer free after all this treatment but got HoLEP to proceed with radiation, but outcome is nothing there to radiate. My story for now and will see future development. Wishing all with PC stay positive and stay on top of it. Best to all. Scott

Interesting development Scott. I too has lupron and Erleada for 13 months and stopped it 8 months ago. I am in remission and hope to remain there for a very long time. I had no terrible side effects from those meds. Good luck to you and I hope that you have a very long and very happy journey