Eliquis and severe osteoarthritis -- it's a problem, for sure. I had relied on prescription NSAIDS for decades when I was diagnosed with Afib and prescribed Eliquis. I stopped taking the NSAID and was immobilized within weeks, finally started taking the NSAID because I reckon it is important for me to keep moving. I've done a a lot of reading about this. The ARISTOTLE study is scary but osteo docs say that if you are on Eliquis, then Celebrex 200 mg once a day with a PPI is the least bad option. I make sure to take it with food. And I re-evaluate my decision frequently -- I'm in the midst of one of those re-evaluations right now. Pretty sure there is no one-size-fits-all answer . . . wishing you well with your decision-making . . .