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Kidney Biopsy Complication

Transplants | Last Active: Aug 21, 2023 | Replies (21)

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@tjdog

I’m 4 years out from my 2nd kidney transplant. First one was in 1994. Last year my creatinine got a little higher than my normal 1.4. It was 1.9, but it does tend to fluctuate.

Instead of having a biopsy to check for rejection, my nephrologist had me do a relatively new non-invasive test. It’s a blood test called Prospera. A company called Natera came to my house to draw blood.

It took a few weeks to get the results. There was no sign of rejection. I don’t know if everyone would qualify for this test.

Here is the website for Natera/Prospera:

https://www.natera.com/organ-health/prospera-organ-transplantation-assessment/

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Replies to "I’m 4 years out from my 2nd kidney transplant. First one was in 1994. Last year..."

Hello @tjdog 😊
It's so great to hear from you!
You included excellent information about the new biomarker noninvasive blood tests. Thank you for the link, this is important information for everyone!
I am so happy to hear that you avoided the invasive biopsy and had the blood test instead.
Has your creatinine returned closer to the 1.4 or is it still elevated or bouncing around?
Are they going to continue to search for the cause of the elevated creatinine with an ultrasound or something like that? Or is your team satisfied that it's fluctuating between 1.4 and 1.9 and no biopsy needed?
Thank you again @tjdog 😊 for joining in the discussion!

Hi there,

My husband is in his 2nd year of kidney transplant. I believe he participated in this Prospera research test between his 4 month and 1 year checkup. Mayo Az set everything up and Natera sent a nurse to our home(we live in Calif) to draw blood but I don't believe we ever heard about the results. For 2nd year checkup his transplant team says he has the option of doing a kidney biopsy(needs to be done on site) or can possibly do Prospera. The transplant neph did say though if it were him he would do a biopsy for the 2nd year checkup because it would screen for early detection of early rejection. He says the kideny biopsy would be a more accurate measure of any rejections but of course there are possible risks!!
The third year will just be lab draw which can be done remotely and would just be a video visit.