There is a lot in your post. Instead of answering your philosophical question, I will focus on the being uncomfortable all the time. If it was me, being uncomfortable would certainly have a major effect on my mood and how I felt. That is very understandable. Perhaps your doctor does not understand the extent of the discomfort. Maybe there is more that could be done. Maybe there are interventions that you haven't tried yet. I don't know.

John Kabat-Zinn is the author of a book called Full Catastrophe Living. It is the result of his work at a pain clinic at a hospital in Boston. Patients were referred to him who had pain that could not be treated. The only way to ease their suffering was to help them to think differently. His basic idea is that the effect of pain or discomfort depends a lot on how you think about it. He makes use of ideas from mindfulness meditation. For me personally, this book has little to woo-woo, but my other experiences with mind training makes me sure that there is something of value in the general direction of mindfulness. His book is not the only source of information about mindfulness and meditation. There may be other books on mindfulness available for free in your public library. My library has a program whereby they will mail books to people like me who are unable to physically get to the library.

For me personally, I get some satisfaction in using my precious (and short) human lifetime to the best extent that I can. There is a lot of need in the world. Somewhere there is someone who needs what you have to give.