I had my first (and last!) Prolia shot on 4/6/23. It was fine for 6 days. On day seven I woke up with so much pain I could not get out of bed. Severe pain in hips, spine and legs left me unable to walk. My vision was so blurred I couldn't drive a car. I have neuropathy and sciatica which were well controlled with medication. After Prolia, they both blew up, out of control. I had 2 uti's within a month (I hadn't had a UTI in 20 years). That's just the highlights. It took about 3-4 months to get completely back to normal. When I told my endo what happened, he didn't deny that it was the Prolia, but said it wasn't a normal reaction. Well, no kidding! I wonder if all these serious reactions are not normal because they never get reported? In any event, I won't be taking any of these meds in the future. I've had fractures, the Prolia was worse.