Hi Scoop & @spider109, I take both as part of my daily med/supplement routine. Upon rising in the AM and again between 8-10PM. As oral meds, they take some time (days) to be really effective in the body. I also use a Symbicort inhaler twice a day.

LET ME STRESS, this is a routine that I have worked out for my own particular thick, sticky mucus that has plagued me all my life. I have also had asthma & severe allergies for many years. My primary and pulmonologist are happy with how it works for me. You and your body are different, and your situation may vary.

My ENT started me on the Mucinex nearly 40 years ago to help with persistent inner ear fluid (that when drained resembled thick yellow glue) and thick sinus mucus - both of which led to dozens of infections. It cut the infections to 1-2 per year from 10 or more.

After I was diagnosed with MAC & Bronchiectasis 5 years ago, I learned about NAC/glutathione here and on another Bronch site. I did some research and decided to give it a try. But I was unwilling to inhale liquid glutathione as I have highly reactive airways and was afraid to add one more substance. Also, the NAC has anti-inflammatory properties and I have arthritis & other inflammatory issues, so I thought, hmmm... It helps me.

Finally, unless I am having a flare or exacerbation, I no longer neb saline twice a day, though I faithfully do airway clearance. My "magic number" for nebs this summer has been just 2-3 per week (I don't currently seem to have MAC) preceded by my Symbicort inhaler. Let me say, I really though I was walking a dangerous line there - or being a "slacker" until I watched one of the videos from the recent European Bronchiectasis conference where I learned it is an acceptable practice for stable situations:

What routine do you use?
Sue
PS I did some stretching & meds before I sat down to read Connect. Now my lungs are ready to clear so I am blowing on my Aerobika and huffing as I write. Multitasking at its finest.