Hello @whidbey and welcome to Mayo Connect. @kelliw is a Camzyos champion and her advice is spot on! I hope you are able to contact your doctor or as kelliw mentioned the specialty pharmacist or nurse navigator for any concerns. This is a new drug and every person is unique and will have a different response. Some it seems respond quickly and others take much longer to see results. I have no experience with Camzyos as I had to have a septal myectomy. But I can tell you this much, this group of Camzyos people are amazing! This group is very supportive of each other and willing to share their experiences in the hope that it helps someone else. How long have you known you had HOCM? Is your doctor specialized in treating HOCM?