I am sorry to hear about your brother. I'm not sure where you are in this world, but anybody that has any tough neurological issues, I recommend that Dr Elizabeth Peckham at Central Texas Neurology. They assign many specialist doctors to every patient. I had a 7 doctor team there. I also had a 7 doctor team at the Mayo Clinic, my lead doctor was Dr Kantarci (I think that's spelled correctly). They may only diagnose, but they also send you in the best direction in their opinion. I'm still going through doctors in this and have not made any advancements. But I'm meeting you people and learning more and learning more potentials for hopefully a brighter future. Thank you for your input. And tell your brother he is not alone. Just fight, fight through as much pain as he can. Fight for something, like I was still raising my teenage daughter at the time I originally posted here. Now my daughter is grown and out living with her boyfriend. It's amazing how being alone can be so difficult and I can afford you it's very lonely with feeding tubes, multiple implants in my spine, screws and plates in my spine and most recently my hand. Because I fell and got a tiny cut on my thumb and it just happen to cut my flexor tendon in half. They reattached it, but I have connective tissue disorders and my thumb would never work again. So they drove a large screw right down the tip of my thumb so the way down to connect both thumb bones into one permanent straight bone. I wish you and your brother all the best!