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Do Prolia injections affect the kidneys?
Osteoporosis & Bone Health | Last Active: Jul 3 12:06pm | Replies (88)Comment receiving replies
@shani here is a discussion of Prolia and kidneys
https://connect.mayoclinic.org/discussion/i-have-been-on-prolia-injections-for-2-years-now-my-kidneys/?pg=2
Here is what the drug insert says:
"Denosumab may cause low calcium levels, especially if you have kidney problems. Take calcium and vitamin D as directed by your doctor. Your doctor will order calcium blood tests before your first injection and during treatment."
And here is a study:
https://pubmed.ncbi.nlm.nih.gov/34319515/
Conclusion: With optimization of CKD-MBD, calcium and vitamin D supplementation, and close monitoring, denosumab can be considered in CKD. There are however opportunities to better understand its fracture efficacy and safety in an RCT setting.
Replies to "@shani here is a discussion of Prolia and kidneys https://connect.mayoclinic.org/discussion/i-have-been-on-prolia-injections-for-2-years-now-my-kidneys/?pg=2 Here is what the drug insert..."
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@shani you can actually get off Prolia by switching to Reclast, and you may not need to stay on Reclast long term. Many of us are reading Dr. Keith McCormick's book "Great Bones" and watching Dr. Ben Leder's video on sequencing and combinations.
The gist is you want to do blood tests- P1NP and CTX- to get the timing right for a switch to Reclast. Too early and it won't work and too late means fractures.
My kidneys are doing the exact same thing- same numbers- and I am not on Prolia!!