Connect
← Return to Do Prolia injections affect the kidneys?
Discussion
Do Prolia injections affect the kidneys?
Osteoporosis & Bone Health | Last Active: Jul 3 12:06pm | Replies (88)Comment receiving replies
I have been on Prolea for 5 years and among all the other issues I have had a spontaneous hip fracture, 2 strokes, several autoimmune diseases, being told if I come off the Prolea, I’ll have terrible fractures, I too walk 1-2 miles a day, have taken Ca since my kids were born 50+ years ago, worked full time up until that hip fracture, etc…all the right things, now have kidney failure. I am ready to boycott all drug companies and their followers…meaning the ‘’sheep’’ docs and their platitudes!I unequivocally empathize with all the responses here…my favorite go-to place for critical, straight information because docs and drug companies lie through their teeth about nearly everything these days so no sane answers from them! I’ve about had it!
Replies to "I have been on Prolea for 5 years and among all the other issues I have..."
So sorry too hear all your going through. Although I haven’t had your severe side effects, I have had serious mouth issues. Failed bone graft, infections, pain & no longer can eat or bite in the front or left side of my mouth. I went too several specialists & they took me off Prolia. Then Forteo! I called Lily regarding Forteo about the high cost & they wouldn’t help. So Evenity was my last option. Just had my first two injections. What are these drug companies doing too us? The side effects are bad no which drug you choose. My Rheumatologist told me I’m damned if I do & damned if I don’t! Hope you feel better & I wish you the very best!
Connect
@shani here is a discussion of Prolia and kidneys
https://connect.mayoclinic.org/discussion/i-have-been-on-prolia-injections-for-2-years-now-my-kidneys/?pg=2
Here is what the drug insert says:
"Denosumab may cause low calcium levels, especially if you have kidney problems. Take calcium and vitamin D as directed by your doctor. Your doctor will order calcium blood tests before your first injection and during treatment."
And here is a study:
https://pubmed.ncbi.nlm.nih.gov/34319515/
Conclusion: With optimization of CKD-MBD, calcium and vitamin D supplementation, and close monitoring, denosumab can be considered in CKD. There are however opportunities to better understand its fracture efficacy and safety in an RCT setting.