Having been married for 38 years, I have some thoughts...initially, we had a tremendous sexual relationship. We had our daughter after 11 years of marriage (following the loss of twin boys the year earlier at 5 months). Turns out, my wife had Muscular Dystrophy which was diagnosed during her pregnancy with our daughter. That was 26 years ago. Her MD has caused her to steadily lose abilities and significantly reduced her quality of life. She requires a walker in the house, help to get off the couch, toilet, ect and weakens very quickly. I can't touch her due to her instability while walking (so no hand holding or arms around each other, ect. ) Over the years, I have become more and more of a care-giver and less and less of a partner. In fact, I feel more like her room mate than her husband. Sex ceased several years ago. She did a lot of research and we both decided hormone replacement therapy would improve the quality of our lives and maybe re-ignite our sex lives(she is 61 and I am 66). Unfortunately, although her quality of life has significantly improved, a breast cancer bout 7 years ago prevented her from receiving estrogen so she gets some testosterone and progesterone. I get a large dose of testosterone. I feel great, lift weights at the gym 3 days each week and weigh 6 pounds heavier than I did in high school. Never smoked and in overall great health. However, with all the testosterone swirling around inside of me, I feel like I did in high school and my desire for my wife is almost uncontrollable. She has no such attraction for me and suffers from low desire, dryness, atrophy and overall weakness(estrogen is the woman's testosterone for desire and she has none). Obviously, I can't initiate anything with her so I am "on my own" which is not satisfying . When I tell her I will cease the pelleting at my next scheduled appointment(every 6 months) because it makes me too amorous for her, she becomes angry with me and tells me maintaining pelleting to maintain my health is more important than struggling with unfulfilled desire. I find myself scanning women at the gym (I would never cheat but I feel 16 again) and struggle to keep my resentment at bay.