To HBP.
Your treatment with Erleada and ADT was stopped at 13 mos.
Could you share the reason your treatment was discontinued .
I have been on Lupron for 15 mos and Zytiga for 11 mos. The treatment plan is for another year.. I feel like crap
I am 76 with G-7+, PSA Hit 80+, pelvic Lymph nodes involved.
Thanks for any input.
Jim
Yes, Lupron is a bitch. I’ve been on for a little over five years and also take a Zytiga with prednisone. It has kept me alive so I have learned to live with all its side effects and I think I’ve had most of them. After five years, my PSA has finally started to rise slowly took eight months to get from undetectable to .5 did a PSMAA scan had 2 small optics one in my scapula one and a rib radiologist said too small to radiate so I’m waiting to see if they grow. They are keeping me on ADT bc they are not sure if I am really castrate resistant. So maybe ADH is still working.
A 64 old with GS 4+3 T3B. Overall health. Dr said cancer is aggressive. After prostatectomy surgery in April, he said cancer escaped to seminal vesicle. PSA is rising from 0.047 in June to 0.067 in July. Oncology suggests ADT & Radiation treatment now. Can't do PSMA scan as PSA is undetectable now. ADT is for 18-24 months with Trelstar injection & bicalutamide pills; Radiation: 5 days/wk for 20 days. Not sure what side effects from these drugs (anyone knows??). Should wait for PSA to be detectable (>=0.1) to see if cancer spreads or do the ADT & Radiation treatment now? ..... Now I know how people in this community feel when it comes to make such big decision.
Aggressive cancer with a rapidly rising PSA requires an immediate aggressive treatment. It sounds like you are in good hands and you got good advise. Good Luck
A 64 old with GS 4+3 T3B. Overall health. Dr said cancer is aggressive. After prostatectomy surgery in April, he said cancer escaped to seminal vesicle. PSA is rising from 0.047 in June to 0.067 in July. Oncology suggests ADT & Radiation treatment now. Can't do PSMA scan as PSA is undetectable now. ADT is for 18-24 months with Trelstar injection & bicalutamide pills; Radiation: 5 days/wk for 20 days. Not sure what side effects from these drugs (anyone knows??). Should wait for PSA to be detectable (>=0.1) to see if cancer spreads or do the ADT & Radiation treatment now? ..... Now I know how people in this community feel when it comes to make such big decision.
A 64 old with GS 4+3 T3B. Overall health. Dr said cancer is aggressive. After prostatectomy surgery in April, he said cancer escaped to seminal vesicle. PSA is rising from 0.047 in June to 0.067 in July. Oncology suggests ADT & Radiation treatment now. Can't do PSMA scan as PSA is undetectable now. ADT is for 18-24 months with Trelstar injection & bicalutamide pills; Radiation: 5 days/wk for 20 days. Not sure what side effects from these drugs (anyone knows??). Should wait for PSA to be detectable (>=0.1) to see if cancer spreads or do the ADT & Radiation treatment now? ..... Now I know how people in this community feel when it comes to make such big decision.
I think that you are on the right (and unfortunate) path.
Jan 17, 2023 webinar from PCF.org; prominent Med Onc & Rad Onc discussing rising PSA after Tx.
Med Onc said he takes note of rising PSA over .03. They are initiating salvage tx sooner than later, and based on individual case. And not waiting necessarily for PSA to rise further.
Suggested that earlier intervention in aggressive disease may be of greater benefit.
At least that was my takeaway.
I failed 1st postop 90 day PSA @ 0.19. Pathology reported G 9 and EPE.
After a false start, tx initiated w/in 3 mos; IMRT to whole pelvic region (WPRT) and ADT.
Note: My ADT course was short; 4 mos. Not entirely sure why, but center of excellence tx plan for me. Waiting for 6 mo post salvage tx PSA verdict in Nov.
Length of ADT may be something to revisit/confirm after tx initiated, and depending upon your response to the ADT.
Prayers and best wishes to you and to all.
A 64 old with GS 4+3 T3B. Overall health. Dr said cancer is aggressive. After prostatectomy surgery in April, he said cancer escaped to seminal vesicle. PSA is rising from 0.047 in June to 0.067 in July. Oncology suggests ADT & Radiation treatment now. Can't do PSMA scan as PSA is undetectable now. ADT is for 18-24 months with Trelstar injection & bicalutamide pills; Radiation: 5 days/wk for 20 days. Not sure what side effects from these drugs (anyone knows??). Should wait for PSA to be detectable (>=0.1) to see if cancer spreads or do the ADT & Radiation treatment now? ..... Now I know how people in this community feel when it comes to make such big decision.
I have a very aggressive PC. Gleason 9. I would go ahead with ADT and radiation if I were in your situation. No need to wait until cancer spreads. ADT has nasty side-effects but kept me alive. Is not that the main reason we fight? Take care. Wish you the best.
Yes, Lupron is a bitch. I’ve been on for a little over five years and also take a Zytiga with prednisone. It has kept me alive so I have learned to live with all its side effects and I think I’ve had most of them. After five years, my PSA has finally started to rise slowly took eight months to get from undetectable to .5 did a PSMAA scan had 2 small optics one in my scapula one and a rib radiologist said too small to radiate so I’m waiting to see if they grow. They are keeping me on ADT bc they are not sure if I am really castrate resistant. So maybe ADH is still working.
78 on Xtandi and Xgeva No side effects Had L1 radiated 1 cinch our Now in L2 and small spot in T 11 T 10 Feel great Zolodex shot 3 months 40 rads in 2017
I am 65 and was diagnosed ( 1 year ago ) I get a Lupron injection every 6 months compared to many I have read get one every 3. A bit more potent I presume ( 2 to 1 ratio) . I am also on Abiraterone and prednisone. What some call hot flashes , I call heaters, as they can pop up at any given moment and cause instant sweats. Also developed some serious muscle pain in the very large muscles in my back. I have also experienced drops in blood pressure ( vagal nerve response ) that causes my blood pressure to go as low as 40/20 and have got hauled out of my home and public places by ambulance 4 or 5x in the last 9 months !! Very unpleasant near death experiences !! BUT , I’m still alive and wouldn’t be now if not for the meds !!
1 week after my diagnosis I was unfortunate enough to slip on my outside deck steps and my leg actually went under the steps and all my weight came down and I Cracked my Femur right IN HALF right above my knee !! Uh, I have felt many types of nasty pain ( horrible back pain for one ) in my life BUT never anything even remotely close to this type of pain !! Doctors use a scale of 1 to 10 to rate pain. This pain went so far over a 10 that if I say it was a 100 on a pain scale I may be low !! I was in a Medical Center hospital for 2 weeks with a broken leg that required traction and major surgery that left me with a 3 foot titanium rod and more screws than a box of screws in my leg and knee !!
Very aggressive cancer and a broken femur all in one week !!! Murphy’s Law : Anything that can go wrong will go wrong !! Lucky me ✌️
I am 65 and was diagnosed ( 1 year ago ) I get a Lupron injection every 6 months compared to many I have read get one every 3. A bit more potent I presume ( 2 to 1 ratio) . I am also on Abiraterone and prednisone. What some call hot flashes , I call heaters, as they can pop up at any given moment and cause instant sweats. Also developed some serious muscle pain in the very large muscles in my back. I have also experienced drops in blood pressure ( vagal nerve response ) that causes my blood pressure to go as low as 40/20 and have got hauled out of my home and public places by ambulance 4 or 5x in the last 9 months !! Very unpleasant near death experiences !! BUT , I’m still alive and wouldn’t be now if not for the meds !!
1 week after my diagnosis I was unfortunate enough to slip on my outside deck steps and my leg actually went under the steps and all my weight came down and I Cracked my Femur right IN HALF right above my knee !! Uh, I have felt many types of nasty pain ( horrible back pain for one ) in my life BUT never anything even remotely close to this type of pain !! Doctors use a scale of 1 to 10 to rate pain. This pain went so far over a 10 that if I say it was a 100 on a pain scale I may be low !! I was in a Medical Center hospital for 2 weeks with a broken leg that required traction and major surgery that left me with a 3 foot titanium rod and more screws than a box of screws in my leg and knee !!
Very aggressive cancer and a broken femur all in one week !!! Murphy’s Law : Anything that can go wrong will go wrong !! Lucky me ✌️
Can’t the doctors give you something for pain that you only take when you need it or at least get you to a rehab center to address the pain until it is manageable? I am sorry to hear about your difficulties and I hope that the doctors are able to address your isdurs
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Hug
Yes, Lupron is a bitch. I’ve been on for a little over five years and also take a Zytiga with prednisone. It has kept me alive so I have learned to live with all its side effects and I think I’ve had most of them. After five years, my PSA has finally started to rise slowly took eight months to get from undetectable to .5 did a PSMAA scan had 2 small optics one in my scapula one and a rib radiologist said too small to radiate so I’m waiting to see if they grow. They are keeping me on ADT bc they are not sure if I am really castrate resistant. So maybe ADH is still working.
A 64 old with GS 4+3 T3B. Overall health. Dr said cancer is aggressive. After prostatectomy surgery in April, he said cancer escaped to seminal vesicle. PSA is rising from 0.047 in June to 0.067 in July. Oncology suggests ADT & Radiation treatment now. Can't do PSMA scan as PSA is undetectable now. ADT is for 18-24 months with Trelstar injection & bicalutamide pills; Radiation: 5 days/wk for 20 days. Not sure what side effects from these drugs (anyone knows??). Should wait for PSA to be detectable (>=0.1) to see if cancer spreads or do the ADT & Radiation treatment now? ..... Now I know how people in this community feel when it comes to make such big decision.
Aggressive cancer with a rapidly rising PSA requires an immediate aggressive treatment. It sounds like you are in good hands and you got good advise. Good Luck
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Hug
1 ReactionI'm convinced that the family of ADT drugs have the same side effects as they are all working to reduce testosterone.
I think that you are on the right (and unfortunate) path.
Jan 17, 2023 webinar from PCF.org; prominent Med Onc & Rad Onc discussing rising PSA after Tx.
Med Onc said he takes note of rising PSA over .03. They are initiating salvage tx sooner than later, and based on individual case. And not waiting necessarily for PSA to rise further.
Suggested that earlier intervention in aggressive disease may be of greater benefit.
At least that was my takeaway.
I failed 1st postop 90 day PSA @ 0.19. Pathology reported G 9 and EPE.
After a false start, tx initiated w/in 3 mos; IMRT to whole pelvic region (WPRT) and ADT.
Note: My ADT course was short; 4 mos. Not entirely sure why, but center of excellence tx plan for me. Waiting for 6 mo post salvage tx PSA verdict in Nov.
Length of ADT may be something to revisit/confirm after tx initiated, and depending upon your response to the ADT.
Prayers and best wishes to you and to all.
I have a very aggressive PC. Gleason 9. I would go ahead with ADT and radiation if I were in your situation. No need to wait until cancer spreads. ADT has nasty side-effects but kept me alive. Is not that the main reason we fight? Take care. Wish you the best.
-
Like -
Helpful -
Hug
3 Reactions78 on Xtandi and Xgeva No side effects Had L1 radiated 1 cinch our Now in L2 and small spot in T 11 T 10 Feel great Zolodex shot 3 months 40 rads in 2017
-
Like -
Helpful -
Hug
1 ReactionI am 65 and was diagnosed ( 1 year ago ) I get a Lupron injection every 6 months compared to many I have read get one every 3. A bit more potent I presume ( 2 to 1 ratio) . I am also on Abiraterone and prednisone. What some call hot flashes , I call heaters, as they can pop up at any given moment and cause instant sweats. Also developed some serious muscle pain in the very large muscles in my back. I have also experienced drops in blood pressure ( vagal nerve response ) that causes my blood pressure to go as low as 40/20 and have got hauled out of my home and public places by ambulance 4 or 5x in the last 9 months !! Very unpleasant near death experiences !! BUT , I’m still alive and wouldn’t be now if not for the meds !!
1 week after my diagnosis I was unfortunate enough to slip on my outside deck steps and my leg actually went under the steps and all my weight came down and I Cracked my Femur right IN HALF right above my knee !! Uh, I have felt many types of nasty pain ( horrible back pain for one ) in my life BUT never anything even remotely close to this type of pain !! Doctors use a scale of 1 to 10 to rate pain. This pain went so far over a 10 that if I say it was a 100 on a pain scale I may be low !! I was in a Medical Center hospital for 2 weeks with a broken leg that required traction and major surgery that left me with a 3 foot titanium rod and more screws than a box of screws in my leg and knee !!
Very aggressive cancer and a broken femur all in one week !!! Murphy’s Law : Anything that can go wrong will go wrong !! Lucky me ✌️
-
Like -
Helpful -
Hug
4 ReactionsThat is a lot of trouble and hard times.
Hope you are doing a bit better.
Best wishes for recovery from all.
Can’t the doctors give you something for pain that you only take when you need it or at least get you to a rehab center to address the pain until it is manageable? I am sorry to hear about your difficulties and I hope that the doctors are able to address your isdurs