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Do Prolia injections affect the kidneys?

Osteoporosis & Bone Health | Last Active: Jul 3 12:06pm | Replies (88)

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@trinity

Hi Peggy! I live in the village of Wilcox, PA..It is considered NW PA. As you have reviewed my postings, 1 PROLIA INJECTION AND MY GFR PLUMMETED 12 POINTS...My second one was on 3/25....If labs were done prior to the injection and I reviewed them, I would have definitely opted out! !!! I am supposed to have both PTH AND GFR repeated...I still waiting for the order from my rheumatologist. ..I thought midway about 3 months to check the values....I AM DONE WITH PROLIA...I am 67 years old and a retired Director of Nursing...I have also contacted the FDA RELATED TO THIS...PLEASE CHECK YOUR GFR VALUES DURING YOUR COURSE OF PROLIA TREATMENT...IF IT HAS BEEN A CONTINUOUS DECLINE YOU INDEED HAVE SOMETHING TO REPORT....SOUNDS like you are otherwise healthy...Please keep me apprised of progress...Oh, first I started with BONIVA for about 10 years; my stomach was horrible...I had such GI DISTRESS...NEXT was RECLAST...I had a total of 3 infusions...Insurance dictated no further payment or recommendation...Then last year I decided to see a rheumatologist again...Hence PROLIA...My DEXA SCAN IS DONE EVERY OTHER YEAR PER MEDICARE...IN MY age bracket, the bone changes are slower in degeneration now..I WILL continue to walk daily and be active...U have always walked 5 miles daily...I will post after my labs; however, none of us are thrilled to enter the hospital setting for labs due to the COVID 19...I have seen other declines in GFR ON THIS MAYO CLINIC SITE...We as a group need to report negative findings to both the FDA AND PROLIA FOR THEIR ADVERSE REACTIONS. ..KEEP IN TOUCH AND THANK YOU SO MUCH PEGGY...

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Replies to "Hi Peggy! I live in the village of Wilcox, PA..It is considered NW PA. As you..."

Hi Trinity. My armpit is NEPA just outside of Harvey's Lake. I am also 67 but not retired yet (although this shut down could put the small dental lab, where I do crown and bridge, out). I started out with fossamax when I was 50. Developed some bone or muscle pain after a few months so was switched to actonel. Took that for 10 years and they then said "Oh, you shouldn't be on it so
long". So it was stopped. Two years ago I was advised to continue some kind of treatment so after consulting a rheumatologist prolia was chosen. I have had four rounds of tests. On 8-3-18 bun was 26, creatinine was 0.9, and gfr was >60. On 3-18-19 bun was 21, creatinine 1.0, gfr was >60. On 10-23-19 bun was 20, creatinine was 1.0, and gfr was 58.7. This time 5-15-20 the bun was 21, the creatinine was 1.2 and the gfr was 47.7! Wow! That was hard to get right with stupid auto-correct! So now they have called me to advise me to see my pcp. The bun number was the red flag but not the gfr???? Are you kidding me? That gfr number puts me in a stage three kidney disease catagory. I take calcium and D everyday. Exercise 45 minutes every other day. Eat a reasonably healthy diet and drink an average amount of liquids. Have no symptoms of kidney issues ,yet. Urine is clear to light yellow. I know they give you all the bad possibilities of stopping prolia but do they outweigh the probability of destroying kidneys? Can kidney function be improved? I'd really like to keep my kidneys in good shape. What are other options for the bones? Is an alkaline diet very useful? I understand it would be quite hard to follow. Thank you so much for responding to my message so quickly. I joked to my husband that I have a "bone buddy". Oh, and I did not capitalize the drugs because I did not think they were entitled to the respect. With the numbers I have what would you do? I'd like to think there are other options but other than diet I'm not sure.