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Do Prolia injections affect the kidneys?

Osteoporosis & Bone Health | Last Active: Nov 14, 2023 | Replies (85)
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@trinity

Yes, my PTH WAS ELEVATED prior to my first injection and D was very low, calcium was normal....I assumed my parathyroid was producing more in compensation...Yes, prescription strength D3...Also at that time my GFR WAS 83.5....Six months later calcium still normal, PTH STILL HIGH and GFR dropped 12 points...I am concerned about my kidney function....Every other lab is nprmal...I think prolia may be the culprit for the decrease in GFR....As for the parathyroid I am stumped...Rheumatologist plans on checking PTH AND GFR IN A FEW WEEKS. IF my results are not favorable, I may not continue with Prolia...As for the elevated PTH, TUMOR??I think more tests are needed..The b vitamin D deficiency has been ongoing...When you live in the armpit of PA where the sun doesn't shine, lol..

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Replies to "Yes, my PTH WAS ELEVATED prior to my first injection and D was very low, calcium..."
Teresa, Volunteer Mentor | @hopeful33250 | Apr 10, 2020

I understand, @trinity. I live in Michigan, also a place with little sun! I find it interesting that you also have a high PTH but normal calcium level, much like me. Have you had the nuclear scan of the Parathyroid to look for adenomas? I recently had it and it appeared normal.

If you don't mind sharing more, how low is/was your D level? Mine was at 17 for a long time. When I increased the supplements to 4,000 (take in two doses, morning and night) it finally got up to 30. My endocrinologist said that taking two separate doses was probably better than taking it all in one dose.

I appreciate your sharing your journey with this problem!

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peggydenmon | @peggydenmon | May 17, 2020

Hi trinity. I also live in the armpit of Pa. I wonder if it is the same armpit. I started on Prolia and am due for my 4th shot this Thursday. I got the results from my blood work and was shocked with the GFR number. It does make me wonder if it's worth it. I've been relatively healthy my whole life and I don't want to "kill" my kidneys. Actonel didn't help and I was on that for 10 years. I'm really considering stopping the shot to save my kidneys. Although what alternatives work to improve the bones? Have you found out any more options?

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