Breast cancer 90% estrogen and 10-20% progesterone

@denise66 my HER2+ changed to HER2- from biopsy to post-surgical pathology so I guess you never know. Your estrogen score looks great!

This is what I found online (see below) but talk with a doc- it looks dated. Have you met with an oncologist? It looks like any conclusion is controversial, and mostly relates to negative PR. I also saw that there are sometimes false negatives. With ER+ and HER2- you will have an Oncotype Dx test that will determine treatment.

There is no way to tell when certain online info was posted. The above looks about 10 years old. There might be more recent research that your doctor can share. Also breastcancer.org is a great resource.
https://oncologypro.esmo.org/education-library/factsheets-on-biomarkers/pr-in-breast-cancer
PR as a Prognostic Biomarker in Breast Cancer
PR is a valuable prognostic biomarker in breast cancer, with overall survival, time to treatment failure/progression, and time to recurrence positively related to PR levels.4

Low/absent expression of PR in ER-positive breast tumours is associated with more proliferative and aggressive disease, poorer prognosis and recurrence, whilst PR-positive/ER-positive tumours have more favourable clinico-pathological parameters and prognosis.

PR as a Predictive Biomarker in Breast Cancer
The predictive value of PR status is controversial.4 Some reports suggest that PR-positive patients are more responsive to hormonal therapy;5 however, a more recent meta-analysis suggests that given ER status, PR status is not significantly predictive of response to tamoxifen.6

Her2+ and ER+ means there are more tools to treat this cancer. I was PR - so I can’t speak to that but I was grateful to have so many different ways to treat based on these markers. I found that taking hormone suppression felt like I was able to keep doing something to help myself fight cancer.
@denise66 has your doctor given you any indication of treatment choices?

I’m er+ 90-10% my pr was I think 80% on biopsy then only 10% on surgical specimen. I’m her2- my oncologist said they go by the surgical pathology. I’m on Letrozole.

I am estrogen 90and pr was 80 her2- I am taking anastrozole for 5-7 years.
My oncotype is 20.

I just want to thank @auntieoakley for a positive post on treatments for ER+ and HER2+ cancers. So many women have survived thanks to advances in treatment protocols, some fairly recent.

I was HER2+ then HER2- and was lucky enough to treat hormonal factors only. Despite some side effects, I felt safe on aromatase inhibitors for those 5 years.

I have respect for every person who posts on here that side effects are intolerable but I do believe forums are skewed toward that situation so it is important for those who have not suffered many side effects to also post, partly to encourage those who are scared by reports of side effects and don't want to try. I sincerely hope people will at least try. We all go into denial and forget that we are weighing side effects versus higher risk of cancer return- or spread, which is ultimately terminal.

The first battle I took on was to fight breast cancer with everything that I had. Being in my 30s and her2+ before even herceptin was approved for frontline therapy meant multiple surgeries including an oopherectomy. Then taxol, Adriamycin, and Cytoxin cocktail every three weeks until I had my lifetime dose of those drugs. Then traditional radiation for 6 weeks and a boost for a week.
Then we waited until the first relapse, so that I could have herceptin to target the her2+ portion of this grand entertainment. All while spending 15 years on two different endocrine therapies.
I certainly don’t need you to remind me this journey isn’t always roses, but I choose to try and bring hope and encourage others. I also choose to focus on the positives in my life. A life saved by all of those “druggable” targets we are discussing.
I share my journey without writing veiled snark to others (this is not veiled). I don’t know why my comments seem to annoy you, but you could do what I usually do and just keep scrolling.

@auntieoakley I will keep you as a role model if my cancer should spread (after 8 1/2 years). Your post about your struggle was very impactful. I hope people are grateful for the meds, like Herceptin, that are now available. And for those of us with HER2- and ER+ cancers, we often don't do chemo the way patients did in the past. Thank you for your powerful post and for all your work encouraging the rest of us.

I am so supportive of all who have decided the best course of action to fight this ugly disease. I am envious of your success. I am resending my previous post that I hoped would encourage other women that it is reasonable in feeling they wanted to question and understand the options presented to them. My heart goes out to all of us in the search and hope for a full life.

A reminder of my recent post follows.

Wow! If you follow this platform of sharing experiences you realize that the variations are amazing.

Anastrozole is a one size fits all remedy that is prescribed for any who have the words Breast Cancer associated with their diagnosis. It’s intent can’t be challenged and invites anyone taking Anestrozole or its equivalent to be aware of side effects.
The side effects that are the first you are made aware of are so main stream that I angrily say you can find them on the back of a ketchup bottle. The levels after that if you decide to research further do require your attention because they are more specific and more debilitating.
All knowledge and decisions based on that are so individual they run the risk never really wholly connecting with anyone specifically.
Unlike most men, women seek out this connection anyway. Women are looking for that lost ingredient in their situation that allows them to determine whether they can evaluate, understand and decide what is best for them on all the levels that they require and can deal with on a day-to-day basis.

I will say that my process has involved knowledgeable well-intentioned medical staff, friends and forums such as this.

At times I have felt like a hypochondriac as I have received the ‘Tylenol and Bengay’ prescription.
I have gone through the ‘Suck it up’ phase and finally realized decision-making is something we women have all evolved towards and cherish.
Make the medical profession understand the specifics of what YOU are experiencing. Appreciate their input and then decide what you think is best for you. You have something no one else can comprehend or give you. Your experience in this.
Research, listen and endure as much as YOU can and make your decision in the moment you are in as wisely as you can.

I won't post again here, but after reading the ordeal @auntieoakley has endured for more than 15 years, "envy" is not what I feel! There are cancer situations where full commitment to treatment protocols is really the only choice and the road is difficult.

A gentle reminder about the Community Guidelines https://connect.mayoclinic.org/blog/about-connect/tab/community-guidelines/#ch-tab-navigation

In particular I'd like to point out guidelines number 2.

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– Exercise tolerance and respect toward other participants whose views may differ from your own.
– Disagreements are fine, but mutual respect is a must.
– Personal attacks against members or health care providers are not acceptable. Such posts will be removed.

Posts not following the guidelines have been removed. If you wish to contact me about this decision, please use this form: https://connect.mayoclinic.org/contact-a-community-moderator/