If someone is gluten intolerant or has celiac, going GF makes a huge difference in how you feel and in your health, although a few people are asymptomatic with gluten exposure. Some people also have difficulty digesting the complex gluten molecules, particularly as we age. I noticed the change to my GI tract and arthritis a few days after going GF, but long-term damage such as reflux and skin rashes took a few months to disappear.