I had an episode of A Fib and after it was cardioverted they put me on Eliquis 5 mg, twice a day. Within 2 weeks I had a SEVERE onset of numbness in my feet too! Then about a week later I started having muscle spasms all over my body and some weakness too! These spasms are happening 2-4 times every hour, all day and night! And they are not like the spasms you get in a muscle after exercising. I might get a spasm in muscle in the compartment of my thumb, then my whole hamstring, then in between my ribs, all in the same HOUR! And there's this crazy muscle twitching in muscles too. This is super weird because I'm only 59 y/o and have always been very active and exercised daily. I've also felt super fatigued about 2-3 hours after I take each dose of Eliquis. I never, not ever, go to sleep before midnight and never take naps during the day. Since I started taking it I'm dying for a nap at noon and I'm falling asleep every night at 9 pm. The behavior change is so remarkable that my husband has commented how strange it is too. I don't think this medication is nearly as benign as the company is telling the Drs. Never in my life have I said that I just can't take a medication but I'm not going to keep taking this. The side effects are too severe and I feel vaguely like I'm dying.