I started at .5mg LDN for Fibro, after one day I had increased pain so dropped down to .125mg for four days. When I increased to .250mg, I had two nights of severe insomnia, so dropped back to .125 for two days, on the second night I again had bad insomnia, so I stopped taking it two days ago. My sleep is better but I also started taking an extra 50mg Trazodone the last two nights. I've had various degrees of insomnia for 18 months, so I'm not sure if the LDN is responsible or not. I'll start again at the .125 dose soon and see how it goes. I think it helped reduce my pain a bit, so hope I can keep taking it.