I have been a long hauler since April 2022. Because of Me/CFS, I started LD Naltrexone 1.5 in April and after a few weeks jumped to 3.0 and then shortly thereafter 4.5. That titration was too quick for me, I was very irritable , jittery and had worse insomnia. I backed off to 3.0 which I tolerated well. I found that I have to take it at 10:00 in the morning to avoid worsening my insomnia. Just last week I have added 4.5mg three times and 3.0mg four times and that seems to be helping me to have slightly more energy and not as jittery or irritable. It does however affect my short term memory (worse than usual) but my PEM crashes seem shorter duration.