Hello @bhadfield, Welcome to Connect. I'm sorry to hear you had a bad flare up of arthritis in your feet and ankles after your last infusion. If the prednisone helped with the symptoms, I wonder if you might be tapering off too fast. That is a common issue with polymyalgia rheumatica (PMR) when tapering off of prednisone too fast. Have you talked with your doctor about a slower tapering schedule?