I had persistent afib for a year. I tried flecainide, but it did not work. So, I started on dofetilide. It put me into NSR after 2 doses. But then after about a year and a half of NSR, I started having break through afib. So, I then had an ablation, but stayed on the dofetilide until after the blanking period. We then held 2 doses of dofetilide and I went right into afib. I went back into NSR after resuming the dofetilide. I have remained on dofetilide since then and I am scheduled to have another ablation this fall because I want to get off of the meds. I don't like the way they make me feel. The initial loading process for the dofetilide was a piece of cake. I just sat around the hospital room in my pajamas for 3 days. The worse part was the boredom and the hospital food. I do wish I had gone straight to the ablation instead of trying meds. Good luck.