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Has anyone had PC that is very aggressive and a very low low PSA?

Prostate Cancer | Last Active: Jul 23, 2023 | Replies (47)
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@round5

I would be interested in knowing more about your specific cancer. I am also seeing Dr.Kwon and Hugec for my chemotherapy. My cancer more specifically is: metastatic hormone sensitive prostate cancer with diffuse mets and PSA < 1.0 consistent with neuroendocrine differentiation. I am getting ready to go for my 5th of 6th treatment of Docetaxel and Carboplatin via Dr.Hugec at Minnesota Oncology. We drive from Southern Illinois.

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Replies to "I would be interested in knowing more about your specific cancer. I am also seeing Dr.Kwon..."
kam23 | @kam23 | Jul 16, 2023

I tried four patient portals but couldn’t locate the precise wording so I’m going from memory with my wife’s help.
…metastatic pc, hormone sensitive, poorly differentiated, PSA 17 at time of treatment commencement (3 months before starting chemotherapy). Not sure about Mets and endocrine comments. Gleason was 4-5 by university hospital and 5-5 (10) by John’s Hopkins where we got a second opinion (before contacting Mayo).
They talked about Carboplatin but only if I wasn’t responsive to treatment without it.

Six rounds of Docetaxel 3 weeks apart. Twenty radiation fractions to pelvic area and 15 to hilar lymph node (chest). Fatigue from chemo and some temporary loss of taste. (Berries tasted metallic for a few days). Radiation only side effect was a bought of diarrhea after the last dose. Very few side effect other than fatigue.
Lupron has been much more problematic.

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