Hi, I started LDN in March, started at .25 and am now at 1.25, working my way up slowly. I did try the Guanfacine (last month) but it made me really sleepy even at a small dose so I'm just sticking with the LDN. That, plus PT for pain, along with change in diet (lost 22 lbs) and nutritional supplements (mainly vitamins) has helped me a lot. I also use 2 devices to help my nervous system - the Alpha-Stim and the TruVaga. These have helped a lot with anxiety and overall calming down my system. Alpha-Stim uses brainwave technology and TruVaga is a Vagal Nerve Stimulator.
All these except the PT are through a functional medicine Doctor. My PCP referred me to my local LC Clinic a couple of months ago but I have yet to hear from them.
I hope some of what I've said here is helpful! I was in severe GI pain and had terrible anxiety/PTSD type effects, awful brain fog, very bad fatigue a few months ago. I feel about 80-85% better most days now.