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PV and fatigue

Blood Cancers & Disorders | Last Active: Jul 14, 2023 | Replies (92)

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@sap21981

Just wondering if anyone has checked into stem cell therapy/transplant to treat PV??

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Replies to "Just wondering if anyone has checked into stem cell therapy/transplant to treat PV??"

Hi @sap21981, from my research and understanding, a stem cell transplant for PV is rarely used. The condition is generally felt to be managed well with phlebotomies, low dose aspirin, and other medications.

In a small percentage of cases, PV may progress to a more serious blood cancer such as myelofibrosis (MF), myelodysplastic syndrome(MDS), or acute myeloid leukemia AML. Then treatment warrants the undertaking of an Allogenic stem cell transplant with cells from a donor. I can tell you from experience it’s generally a procedure done as a last option of treatment. It can come with risks and side effects but for those who have no other option it can give them a second chance at life.

Some good reading for you:
From Merckmanuals: https://www.merckmanuals.com/professional/hematology-and-oncology/myeloproliferative-disorders/polycythemia-vera

From the leukemia/lymphoma society
https://www.lls.org/sites/default/files/file_assets/FS13_PolycythemiaVera_FactSheet_final5.1.15.pdf
This is a pretty decent article on WebMD explaining the progression of PV.
https://www.webmd.com/cancer/lymphoma/polycythemia-vera-changes-other-cancer
I know you’re relatively new to this diagnosis and I think you’ve started having phlebotomies to reduce your hemoglobin level. This action, along with a medication, may keep you in a good level for a long time without having to consider having a stem cell transplant.
What has your hematologist suggested for you?