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Sinemet (Carbidopa-Levodopa): Does it help for burning legs at night?

Parkinson's Disease | Last Active: Mar 5, 2021 | Replies (10)
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@hillrunner

I get occasional cramping in my calves or hands in the middle of the night. They might last 10-15 minutes and then dissipate. The cramping is painful. I have been on Carbidopa25/Levodopa100 MG 3 tabs a day for approx. 6 weeks. A more prevailing side effect for me is the sleepiness caused by the med, but when it occurs the cramping is very painful.

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Replies to "I get occasional cramping in my calves or hands in the middle of the night. They..."
Teresa, Volunteer Mentor | @hopeful33250 | Jul 4, 2023

Hello @hillrunner

Welcome to the Parkinson's support group on Mayo Connect.

I've been taking PD meds for about 15 years. I take less Carbidopa/Levodopa than you do (once a day I supplement with a Stalevo tablet), but I also have severe leg cramping. I'm really not sure if the leg cramping is caused by the medication or some other health condition or even by Parkinson's itself. It can be hard to sort out the symptoms.

If the cramping continues, it might be a good idea to run it by your PCP to see if there are any other reasons for the extreme cramping. I'm in the process of doing this myself.

As you are new to Connect, please share, as you are comfortable doing so, a bit about your diagnosis with PD. For example, how long ago were you diagnosed, what symptoms led to your diagnosis? As so many of us, struggled for years before our diagnosis, I'm wondering if it was the same for you.

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