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Tacrolimus induced psychosis post liver transplant.

Transplants | Last Active: Jul 20, 2023 | Replies (23)

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@loribmt

Hi @sec1205 That’s a fairly high tacro trough considering the low dosage your’re on. What is the goal your transplant team is shooting for? One of the side effects of a higher tacro trough is mental status change.
You had only mentioned being on progesterone along with the low dose of tacro. But if you’re also on Cellcept and or other meds too, there can be an interaction in medications where one will cause another to not metabolise through the system as quickly, causing a higher trough.
I had that happen when switching from an IV form of antifungal to oral Pozaconozol. My normal trough was 7. With the same dosage of tacro but the new oral med, my trough zoomed up to over 21 + within a couple of days! I was a royal mess and my kidneys went into faiure.
Have you spoken with your team about adjustments to the tacro?

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Replies to "Hi @sec1205 That’s a fairly high tacro trough considering the low dosage your’re on. What is..."

@loribmt hello!
I get labs done weekly, have for 7 months. Goal is to keep liver happy and reduce kindney strain. My kidneys are struggling. Tacro trough fluctuates weekly. Sometimes it's low, then goes high. I have asked for a different med because I feel tacro doesn't like me but not been given any changes. They are aware of my concerns.
Sorry you were also dealing with side effects of medication. They can make us feel pretty crummy. Hope you're better now.