Good evening. LGL’s - the immature granulocytes- can be symptomatic of a variety of conditions. Typically with AML you’re overproducing white blood cells that are immature as a result of your myeloproliferative disease. The over producing cells spill into your blood so the measurements in blood results are higher.
But, as you mentioned, LGL’s can also be an indicator of an ongoing infection that is stimulating your bone marrow to produce high levels of WBC to defend against the infection and released before they are completely mature.

Do you have a fever or signs of an infection?

If that happens, the treatment plan could most be IV antibiotics. As AML progresses you have white blood cells all over the place but they are immature and not functional, making you susceptible for infection. It’s quite common for AML patients to have multiple infections. When I was admitted to the hospital the day I was diagnosed, though I had no indication of infection, I was immediately put on infusions of 3 different IV broad spectrum IV’s as a prophylactic measure. That was common for me during my many months of chemo.
So please keep an eye on your temperature. If it is elevated to 100.3 you need to call your oncologist’s office for direction.

I think it’s a really great idea that your doctor has suggested weekly infusions of an abrogator for you! You’re right, there is nothing to lose but everything to gain. ☺️. What is the name of your new medication?