Great question. My first sign was itching after a soaking bath. I love to soak in my big claw foot tub but alas no more. When I do I break out in hives.
And now I have a question, does anyone have torso pain? I have it so bad right now that riding in a car on a smooth road is painful. And if by chance I hit a bump or pothole, it is excrutiating. Even walking across a parking lot can bring on the pain.
And unfortunately I have to report that Mayo Clinic did not accept my request for an appointment