Sure, people have every right to choose whatever treatment they want. But not particularly comforting to me to hear uninformed people exaggerate the effects that HU has on most patients. My skin has not darkened, I do not have skin ulcers, and I have no skin cancer and can tolerate some sun exposure with a good sun screen. I moved to the Mayo site because their experts like Drs Mesa and Scherber have done some of the most important work on MPNs. I had hoped I would find fewer alternative med fans and HU haters here.