100% ER+ 100% PR+ HERS2- How common is the 100% diagnosis?

Posted by janisbrede @janisbrede, May 2, 2023

When I went to Mayo for a second opinion they saw my initial diagnosis of 100%ER+ 100%PR+ and said that would probably change when they did their evaluation but it came back 100% ER and PR+ as well. Does this mean I am extremely sensitive to hormones? Anyone else 100%...seems drastic to me, not in a good way. I'm worried I should be a little more cautious with what I put in body to try to reduce hormones although I am on Tamoxifen to block hormone receptors. I just don't fully grasp how this is all connected.

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tonna | @tonna | Jun 26, 2023

I had 2 tumors right next to each other. The 1st was Er + 100% and PR+ 95%
Ki67 was 5% Her2 negative....the other was triple positive but not sure of the numbers for that one yet. They were both stage 1. I am 47 and premenopausal. 1 week out of single mastectomy. I chose mastectomy to hopefully skip radiation since tumor was above my heart and full lung. (Had stage 1 adenocarcinoma of the lung removed 7 years ago) I have started limiting my intake of certain foods...I just did a Google search for foods to avoid for estrogen/progesterone positive breast cancer...Good Luck to all!

dyevooshka | @dyevooshka | Jun 26, 2023

In reply to @salamander "I am same diagnosis. March 2023. I am perimenopausal amd startimf tamoxifen soon. So scared!" + (show)

Mine was similar, with both hormones 90% positive, although I gad only stopped taking hormones on October, when my December biopsy showed these results.

windyshores | @windyshores | Jun 26, 2023

The adrenal glands still produce estrogen regardless of what we eat.

It is important to note that the ER and PR percentages do not refer to what is in our body but instead to the degree the cancer responds to those hormones.

Aromatase inhibitors reduce estradiol below detectable levels. I would doubt that any dietary changes can achieve that, but it can't hurt. I have resumed soy because I read positive things about it after prior reading that it was estrogenic.

Many of us have enough health challenges without dietary restrictions! But if no harm. maybe there is some small benefit.

Chris, Volunteer Mentor | @auntieoakley | Jun 26, 2023

In reply to @windyshores "The adrenal glands still produce estrogen regardless of what we eat. It is important to note..." + (show)

Thank you for pointing out this common misconception, about the percentages. It is a very important distinction.
Also most women as long as they have ovaries will produce estrogen in them even after menopause they continue to produce some level of estrogen.
@salamander may I ask what specifically scares you about tamoxifen?

salamander | @salamander | Jun 26, 2023

I know I go down a rabbit hole alot with side effects but estrogen is a very helpful hormone for many reasons and suppressing it has consequences. 😢👩‍⚕️
Did you have to take it?

salamander | @salamander | Jun 26, 2023

In reply to @dyevooshka "Mine was similar, with both hormones 90% positive, although I gad only stopped taking hormones on..." + (show)

I didnt understand your reply…you stopped taking hormones? Can you clarify?

dyevooshka | @dyevooshka | Jun 26, 2023

I was postmenopausal and at 64, had been taking medroxyprogesterone and estradiol for 10 years. We decided it was time to taper off and stop, so I gradually decreased the dose and stopped at the end of October. My breast cancer was found in December.