@jmcaleavey Let me look around for a resource for you. This has been a lifesaver for my husband with chronic pain, probable central sensitization, fatigue, and his rheumatoid arthritis. He has diabetes and Stage 3 kidney disease, so many meds are off the table for him. After one month of titrating up from .5 mg to 2.5 mg he is still looking for the complete sweet spot, but he has his life back! His doc seldom uses more than 3 mg.
He is in a pain rehab program, with PT, a pain doc, a counselor, a Pharm D monitoring and managing his many meds. He has gone from a presence in the recliner to a participant in life. Even wrestle with our daughter's pup on the floor yesterday, and shampooed carpets for me.
So, to answer your question, Mayo doesn't have an article right now but here is one from Cornell:https://weillcornell.org/news/what-you-need-to-know-about-low-dose-naltrexone
Maybe you can ask your doc to refer you to a pain management doc or a doctor of pharmacy. You will also need access to a compounding pharmacy to prepare the med. If there is none near you, a local hospital pharmacy can usually handle it.
Sue