I too was diagnosed with MAC in May of 2015 and have been on the 3 antibiotics since then. I take all three meds on M-W-F, but appreciate the post about splitting it up and taking the Rifampin on different days. I was very nauseated along with diarrhea for the first few months taking the antibiotics, but that has subsided somewhat since taking them all before bedtime. However, I have had a persistent cough for months now which won't go away. I even had an upper GI which showed no reason for the cough. My doctor put me on Prilosec for an unspecified length of time which he said helped him with his cough. I feel like I have phlegm constantly in my throat which causes me to have to clear my throat and then I have coughing spasms. which It is worse at times than others. After 6 months of antibiotics I had another CT scan which showed that the bacteria was the same - no better and no worse. I started taking CBD oil several months ago which helps me sleep better and now am vaping the CBD oil which I am hoping will help the antibiotics work FASTER!!!!