Are you taking a steroid like prednisone or methylprednisolone? That could contribute to osteoporosis, which could make your bones porous ("holes' in your bone is a dramatic way to put it!). Steroids also speed up the heart for some of us. I cannot tolerate a therapeutic dose at all for that reason. But given what is going on, it would seem your immune system needs to be suppressed. Can you talk to your doctor about alternative medications?