The course of my PMR was initial upper body aches and increasing stiffness below the waist to the point it was difficult to walk. Saw my primary care doc, basic rheumatology tests with positive results, 15 mg Prednisone with amazing improvement. Began seeing a rheumatologist, increased Presnisone to 30 mg as 15 wasn't completely alleviating symptoms. Once stabilized, tried on Plaquenil so I could reduce Prednisone but horrible allergic reaction and skin rash to it. Slowly went down to 15 mg Prednisone with aome increase in aches (fatigue was always there). Put on Methotrexate (10 mg weekly, now 15) so Prednisone could be slowly reduced. Now on 10 mg with aches and fatigue I descibed in my question. I also have Smoldering Myeloma.