Looking to connect with people who have non-diabetic neuropathy

I was prescribed OMEPRAZOLE for about 1-2 years from a previous RANIDATIDE prescriprion that was said to be more potent. I developed sensitive peripheral neoropathy at the tip of one toe (second digit/next to great toe). The VA primary doctor has prescribed GABAPENTIN 600mg/day, which I take only prior to sleep. The irritation normally occurs while trying to fall asleep, but sometimes it can irritate while walking or other activity. I quit the OMEPRAZOLE when I found a doctorate's report that said "all the 'AZOLES" have been known in side affect to cause peripheral neoropathy. I found the professional report during a Google search, and I would like some assistance to find that article report again - and if there are any other citations about "the AZOLES" family of PPI's that can complicate a neoropathy condition. Many times now I am seriously considering an amputation rather than saturating my body with up to 1500mg GABAPENTIN + TYLENOL, ASPERIN, and NAPROXEN to boost - and 1 or 2 CYCLOBENZAPRENE that a friend provides in good faith. I get very dizzy from that necessary saturation, and still have to continually massage that toe for a temporary relief. Sometimes I'll end up not sleeping for 24 or 36 hours if I had eaten prior to taking the GABAPENTIN, or did not take enough dosage for an unsuspected severe attack. The GABAPENTIN works best on an empty stomach, and takes a good 2-4 hours to take effect. I have red pimple-like spotted elements all over my skin surface that may be a form of melitus diabeties that may also have pre-disposed me to the neoropathy via introductory affects of the OMEPRAZOLE. I will try to get a VA appointment to see a neoroligist some day, as my VA clinical primary does not have the necessary specialty of this neorologic condition.

I was on the med for 1 and 1/2 years. Checked it out on the internet and, I found out you are NOT supposed to be on OMEPRAZOLE for more then 4 weeks at a time!
I contacted my PCP and told him I wanted off the med! He ordered it prn.
After hearing your tale, I will NEVER take it again.
I have PN from the tips of my toes, to the top of my calves now. Only in 6 short months.
Thanks for the information. Pat!

Here's another note about the OMEPRAZOLE : I never took the full dose of one capsule/day. I divided the 18 pellets that were in each capsule, and and just consumed 6 pellets for a daily dose - which was the minimum to soothe my GERD condition. It may likely be the reason that my "single affected point" neoropathy is justified as a minimal damage exposure. I am currently trying the vitamin regiments off the internet to encourage the so-called Mitochondria to repair the effected nerve - of which some are stating that usually takes several years to travel from the spine of origin to the end of a limb. In contrast, my current VA primary (including the nursing staff) tell me ..."there is no cure". A PCP had given me B-12 along with the Gabapentin, which rhyme's with some of the natural concoctions found on the web. Eventually, the local VA hospital said I had gall stones, and then finally found a 3 cm cialic anyurism via ultra-sound. The CT scan confirmed, and the doctor asked me if I felt pain after eating a large meal...and I get to figure it out later, that I probably never had GERD to begin with. I became fatter after quiting cigarettes, and it took less food in my stomach to put pressure upon the cialic anyurism, that would cause the discomfort after I had eaten. Lazy PCP should have ordered an ultra-sound from the onset of the original complaint. My records altogether will have the evidence to file a VA malpractice claim if it results in amputation, and I think the drug Mfg'rs of Omeprazole should see a day in court likewise for not speaking of the known peripheral neoropathy side affect.

I was prescribed OMEPRAZOLE for about 1-2 years from a previous RANIDATIDE prescriprion that was said to be more potent. I developed sensitive peripheral neoropathy at the tip of one toe (second digit/next to great toe). The VA primary doctor has prescribed GABAPENTIN 600mg/day, which I take only prior to sleep. The irritation normally occurs while trying to fall asleep, but sometimes it can irritate while walking or other activity. I quit the OMEPRAZOLE when I found a doctorate's report that said "all the 'AZOLES" have been known in side affect to cause peripheral neoropathy. I found the professional report during a Google search, and I would like some assistance to find that article report again - and if there are any other citations about "the AZOLES" family of PPI's that can complicate a neoropathy condition. Many times now I am seriously considering an amputation rather than saturating my body with up to 1500mg GABAPENTIN + TYLENOL, ASPERIN, and NAPROXEN to boost - and 1 or 2 CYCLOBENZAPRENE that a friend provides in good faith. I get very dizzy from that necessary saturation, and still have to continually massage that toe for a temporary relief. Sometimes I'll end up not sleeping for 24 or 36 hours if I had eaten prior to taking the GABAPENTIN, or did not take enough dosage for an unsuspected severe attack. The GABAPENTIN works best on an empty stomach, and takes a good 2-4 hours to take effect. I have red pimple-like spotted elements all over my skin surface that may be a form of melitus diabeties that may also have pre-disposed me to the neoropathy via introductory affects of the OMEPRAZOLE. I will try to get a VA appointment to see a neoroligist some day, as my VA clinical primary does not have the necessary specialty of this neorologic condition.

Here's another note about the OMEPRAZOLE : I never took the full dose of one capsule/day. I divided the 18 pellets that were in each capsule, and and just consumed 6 pellets for a daily dose - which was the minimum to soothe my GERD condition. It may likely be the reason that my "single affected point" neoropathy is justified as a minimal damage exposure. I am currently trying the vitamin regiments off the internet to encourage the so-called Mitochondria to repair the effected nerve - of which some are stating that usually takes several years to travel from the spine of origin to the end of a limb. In contrast, my current VA primary (including the nursing staff) tell me ..."there is no cure". A PCP had given me B-12 along with the Gabapentin, which rhyme's with some of the natural concoctions found on the web. Eventually, the local VA hospital said I had gall stones, and then finally found a 3 cm cialic anyurism via ultra-sound. The CT scan confirmed, and the doctor asked me if I felt pain after eating a large meal...and I get to figure it out later, that I probably never had GERD to begin with. I became fatter after quiting cigarettes, and it took less food in my stomach to put pressure upon the cialic anyurism, that would cause the discomfort after I had eaten. Lazy PCP should have ordered an ultra-sound from the onset of the original complaint. My records altogether will have the evidence to file a VA malpractice claim if it results in amputation, and I think the drug Mfg'rs of Omeprazole should see a day in court likewise for not speaking of the known peripheral neoropathy side affect.

I can't find any case study evidence that OMEPRAZOLE causes neuropathy. It does not list neuropathy as side affect.
I've recovered from esophageal cancer and have been taking OMEPRAZOLE twice a day for a while. I have developed neuropathy in feet

Hi @usveteran, Welcome to Connect. I'm not sure if the article you were looking for is one of these but they are on the same topic and may be helpful.

--- How can proton pump inhibitors damage central and peripheral nervous systems?: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716020/
--- Drug-Induced Peripheral Neuropathy: A Narrative Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365998/.

There is another discussion on the topic where you can learn what others have shared on the topic here:
--- Neuropathy + Proton-pump Inhibitor use?? Anyone had this experience?: https://connect.mayoclinic.org/discussion/neuropathy-and-ppi-use-has-anyone-had-this-experience/.

Is it only the one toe with the pain symptoms? Do you think it something other than neuropathy?

Hello, The amount of pain meds you are taking is scary to me. I have neoropathy in 90% of my body and I do not take nearly that amount of meds. If your VA Dr. doesn"t know how to treat it please do not hesitate to see another one. thank you for your service to our country,may God bless you and yours.