Rgwey,
yes, if it is the same mutation, my doctors are hoping Tagrisso will reduce a tumor enough so I won’t need a second surgery. I was also diagnosed with the EGFR Exon 21 L858R mutation in March 2023 after having a wedge and a resection surgery in my right lung. Also a non smoker. After scans and an PET scan surgeon recommended surgery since tumors were 2.4 cm. The surgeon at first thought I had 3 separate different cancers. But the 2 tumors that were removed were both the same EGFR mutation so my oncologist said the other tumor in my other lung most likely is a metastasis. Surgery was put on hold for left lung. I was put on tagrisso end of April. I’ve had several mild side effects, body aches, rashes, diarrhea. The hope is Tagrisso will reduce the tumor so I won’t need the second surgery.

My first CT scan after starting Tagrisso is at the end of June, hoping for good results and a significant tumor reduction . Hoping for good results for your wife also.