I have just returned from my 6 year post op appointment. I had a clear mammogram ! I initially was going to talk about coming off the Tamoxifen as I have now been on it 6 years. My worry was it would affect my bone density. At my appointment I learned that contrary to my belief, Tamoxifen can help prevent bone loss. The standard of care has been 5 years but there seems to be evidence now that 10 years of therapy is better. For that reason I have decided to remain on the Tamoxifen. I am fortunate that I really have no symptoms or side effects except possibly some hair thinning which may or may not be related to the drug. I will be 68 in December and there have been family members that had thinning hair as they grew older. My daughter is an NP and says "stay on the Tamoxifen" and get a wig if you have to ! Lol I think she wants me around a few more years. I will be having a bone density in January and will be anxious to see the results. I had mild osteopenia in my spine only before so hoping I have not had any increases of bone loss.