I have been on Monoprost since 2018 Narrow Angle Glaucoma. Monoprost is Latanoprost with no preservatives.
It gets confusing as I have other illnesses and other medications to find out which ones have side effects.
When I went on Monoprost I was upset to read of side effects including change in eye coour , staining of skin around eyes etc., but i made a list of all the pressure-reducing eye drops and all had/have side effects.
While checking I did notice a short article I think from Australia and the man got depressed when started to take the glaucoma meds., went off them and depression went, back on them and depression came back. Documented. I have not been myself since being on the eye drops but also on dry eye drops - they all enter our bodies but again could be fatigue/depression from other sources. Another problem with meds/drops etc. is the "non-medical" ingredients... we could be ok with the medication/s but not the additives and how the heck do we find out. Thing is, once we are on these drops its for life most times, and even though I had the Iridotomies a couple of years ago (tiny laser holes in eyes to avert pressure build up) we still have to take the drops!! I agree with your description : ... just not myself - I feel the same way but dare not stop the nightly drops!